Synthesis of Tricyclic Quinoline Derivatives from 5- and 6-Aminoindazoles and 5-Aminoindole under Conventional Way and Microwave System

Targeted tricyclic quinolines were prepared from the corresponding aminoindazolic and indolic derivatives as starting materials using two comparative methods; conventional heating microwave irradiation. We noticed that syntheses of 5-amino-1-methylindazole 5-aminoindole abandoned due to their conversion fluorescent products one week after free contact with air acetone. As a result this finding, we decided condense relevant amine acetone or mesityl oxide confirm our hypothesis. show is converted derived quinoline through these condensation processes. Subsequently, reaction was extended aminoindazole positions 5 6, yielding appropriate derivatives. Similarly, exhibited same reactivity. By applying NMR centesimal techniques, resulting structures identified.